Author

R. Fernandez-Leiro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Gonzalez-Corpas· 1 shared A. Lopez-Perrote· 1 shared A. Martinez· 1 shared C. F. Rodriguez· 1 shared C. Garcia-Martin· 1 shared F. G. Johannessen· 1 shared J. A. Hermoso· 1 shared J. Boskovic· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Gonzalez-Corpas

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2 papers

Recent·Most cited

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

O. Llorca, A. Lopez-Perrote, N. Hug, A. Gonzalez-Corpas, C. F. Rodriguez, M. Serna, C. Garcia-Martin, J. Boskovic, R. Fernandez-Leiro, J. F. Caceres

The paper shows DHX34 interacts with RUVBL1-RUVBL2 and alters its conformation to reduce ATP hydrolysis, linking it to NMD activation.

bioRxiv · Sep 28, 2020Biophysics

The structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin

M. I. Flydal, M. Alcorlo-Pages, F. G. Johannessen, S. Martinez-Caballero, L. Skaejrven, R. Fernandez-Leiro, A. Martinez, J. A. Hermoso

This paper presents the first crystal and cryo-EM structures of full-length human PAH with and without BH4, revealing structural dynamics and allosteric mechanisms related to PKU.

bioRxiv · Feb 22, 2019Biochemistry