Author

J. A. Hermoso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

M. Alcorlo· 4 shared D. Straume· 3 shared L. S. Havarstein· 3 shared S. Martinez-Caballero· 2 shared V. Miguel-Ruano· 2 shared A. Diaz-Quintana· 1 shared A. Espaillat· 1 shared A. Izquierdo-Martinez· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersMicrobiology

M. Alcorlo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

J. Li, Y. He, X. Xu, M. Alcorlo, J. Shi, S. Naskar, N. Briggs, D. I. Roper, J. A. Hermoso, L.-T. Sham, M. Luo

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

bioRxiv · Jan 16, 2024 · PreprintMicrobiology

A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha and Betaproteobacteria

A. Espaillat, L. Alvarez, G. Torrens, J. ter Beek, V. Miguel-Ruano, O. Irazoki, F. Gago, J. A. Hermoso, R. P.-A. Berntsson, F. Cava

This paper identifies and characterizes a novel LD-transpeptidase in Gluconobacter oxydans that forms 1,3-type crosslinks, revealing structural and functional differences from known transpeptidases.

bioRxiv · Oct 31, 2023 · PreprintMicrobiology

DipM controls multiple autolysins and mediates two regulatory feedback loops promoting cell constriction in C. crescentus

A. Izquierdo-Martinez, V. Miguel-Ruano, R. Hernandez-Tamayo, J. Biboy, M. T. Batuecas, M. Billini, T. Glatter, W. Vollmer, P. L. Graumann, J. A. Hermoso, M. Thanbichler

This paper identifies DipM as a LytM factor that regulates autolysins through two feedback loops to promote cell constriction in C. crescentus.

bioRxiv · Sep 10, 2022 · PreprintMicrobiology

Structural characterization of the essential cell division protein FtsE and its interaction with FtsX in Streptococcus pneumoniae

M. Alcorlo, D. Straume, J. Lutkenhaus, L. S. Havarstein, J. A. Hermoso

This paper reports the high-resolution structures of FtsE from Streptococcus pneumoniae in complex with nucleotides, revealing its ATPase activity and structural plasticity essential for FtsX interaction.

bioRxiv · Jun 8, 2020Biochemistry

Mitochondrial cytochrome c liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus

K. Gonzalez-Arzola, A. Diaz-Quintana, N. Bernardo-Garcia, M. A. Casado-Combreras, C. A. Elena-Real, A. Velazquez-Cruz, S. Gil-Caballero, A. Velazquez-Campoy, E. Szulc, I. Ayala, R. Arranz, X. Salvatella, J. M. Valpuesta, J. A. Hermoso, M. A. De la Rosa, I. Diaz-Moreno

This study identifies mitochondrial cytochrome c as a factor that releases ARF tumor suppressor from NPM sequestration in the nucleolus upon DNA damage.

bioRxiv · May 7, 2020 · PreprintBiophysics

Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall.

D. Straume, K. Wiaroslawa Piechowiak, S. Olsen, G. A. Stamsas, K. H. Berg, M. Kjos, M. V. Heggenhougen, M. Alcorlo, J. A. Hermoso, L. S. Havarstein

This study identifies a specific role for class A PBPs in processing nascent peptidoglycan synthesized by the divisome in S. pneumoniae.

bioRxiv · Jun 10, 2019Microbiology

The structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin

M. I. Flydal, M. Alcorlo-Pages, F. G. Johannessen, S. Martinez-Caballero, L. Skaejrven, R. Fernandez-Leiro, A. Martinez, J. A. Hermoso

This paper presents the first crystal and cryo-EM structures of full-length human PAH with and without BH4, revealing structural dynamics and allosteric mechanisms related to PKU.

bioRxiv · Feb 22, 2019Biochemistry

Structure of the large extracellular loop of FtsX and its interaction with the essential peptidoglycan hydrolase PcsB in Streptococcus pneumoniae

B. E. Rued, M. Alcorlo, K. A. Edmonds, S. Martinez-Caballero, D. Straume, Y. Fu, K. E. Bruce, H. Wu, L. S. Havarstein, J. A. Hermoso, M. E. Winkler, D. P. Giedroc

This study presents the structure of FtsX's extracellular loop and shows its essential interaction with PcsB for cell viability in Streptococcus pneumoniae.

bioRxiv · Oct 2, 2018Microbiology