Cell lineage as a predictor of immune response in neuroblastoma
S. Sengupta, S. Das, A. Crespo, B. Miller, B. Sharma, S. Zhang, R. Dries, H. Huang, M. Krajewska, D. N. Debruyne, L. Soriano, M. A. Cohen, R. Versteeg, R. Jaenisch, S. Spranger, , R. E. George
This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.
bioRxiv · Jan 29, 2021Cancer Biology