R. Jaenisch

Low-cost camera-based estrous tracking enables transgenesis in Peromyscus leucopus, the primary reservoir for Lyme disease

SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection

This study infects human pluripotent stem cell-derived vascular cells with SARS-CoV-2 and finds that smooth muscle cells drive vascular inflammation and coagulation.

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects

This study shows that fibroblasts from pluripotent cells with single-allele knockouts in two pluripotency genes have DNA methylation issues and reduced pluripotency induction ability.

Development of a physiological insulin resistance model in human stem cell-derived adipocytes

This paper develops a protocol to generate human pluripotent stem cell-derived adipocytes that respond to physiological insulin levels and model insulin resistance in diabetes.

Cell lineage as a predictor of immune response in neuroblastoma

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras

This study develops a mouse-human neural crest chimera model to study human neuroblastoma development and immune interactions in vivo.

One-step generation of monoclonal B cell receptor mice capable of class switch recombination and somatic hypermutation

This paper describes a method to generate monoclonal B cell receptor mice capable of somatic hypermutation and class switch recombination using CRISPR/Cas9.