Author

R. E. George

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Sharma· 3 shared R. Dries· 3 shared S. Sengupta· 3 shared H. Huang· 2 shared M. A. Cohen· 2 shared M. Krajewska· 2 shared R. Jaenisch· 2 shared S. Spranger· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

B. Sharma

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5 papers

Recent·Most cited

The MYCN 5' UTR as a therapeutic target in neuroblastoma

M. P. Volegova, L. E. Brown, U. Banerjee, R. Dries, B. Sharma, A. Kennedy, J. A. Porco, R. E. George

This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.

bioRxiv · Feb 20, 2024Cancer Biology

Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma

X. Qin, A. K. Lam, X. Zhang, S. Sengupta, B. J. Iorgulescu, T. Zuo, A. E. Floru, G. K. Meara, k. Lloyd, L. A. Kwok, K. S. Smith, T. R. Nagaraju, R. Meijers, C. Ceol, C.-T. Liu, , H. Feng

This study shows Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma using human and zebrafish models.

bioRxiv · Oct 3, 2022 · PreprintCancer Biology

Cell lineage as a predictor of immune response in neuroblastoma

S. Sengupta, S. Das, A. Crespo, B. Miller, B. Sharma, S. Zhang, R. Dries, H. Huang, M. Krajewska, D. N. Debruyne, L. Soriano, M. A. Cohen, R. Versteeg, R. Jaenisch, S. Spranger, , R. E. George

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

bioRxiv · Jan 29, 2021Cancer Biology

Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras

M. A. Cohen, S. Zhang, S. Sengupta, H. Ma, B. Horton, G. W. Bell, R. E. George, S. Spranger, R. Jaenisch

This study develops a mouse-human neural crest chimera model to study human neuroblastoma development and immune interactions in vivo.

bioRxiv · Jan 18, 2019 · PreprintCancer Biology

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

M. Krajewska, R. Dries, A. V. Grassetti, S. Dust, Y. Gao, H. Huang, B. Sharma, D. S. Day, N. Kwiatkowski, M. Pomaville, O. Dodd, E. Chipumuro, T. Zhang, A. L. Greenleaf, G.-C. Yuan, , R. E. George

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.

bioRxiv · Nov 30, 2018Cancer Biology