Author

L. Speidel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Assay:whole-genome sequencing· 4 Research Focus:chromatin & epigenetic regulation· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. Skoglund· 3 shared C. Barrington· 2 shared K. Anastasiadou· 2 shared M. Silva· 2 shared T. Booth· 2 shared A. Aqil· 1 shared A. Bricking· 1 shared A. Fischer· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersEvolutionary Biology

P. Skoglund

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever

P. Swali, T. Booth, C. C. S. Tan, J. McCabe, K. Anastasiadou, C. Barrington, M. Borrini, A. Bricking, J. Buckberry, L. Buster, R. Carlin, A. Gilardet, I. Glocke, J. Irish, M. Kelly, , P. Skoglund

The paper analyzes ancient Borrelia genomes to document the evolutionary transition from tick-borne to louse-borne transmission and shows rapid reductive evolution.

bioRxiv · Jul 18, 2024 · PreprintEvolutionary Biology

High-resolution genomic ancestry reveals mobility in early medieval Europe

L. Speidel, M. Silva, T. Booth, B. Raffield, K. Anastasiadou, C. Barrington, A. Gotherstrom, P. Heather, P. Skoglund

This study uses high-resolution genomic ancestry analysis to reveal mobility patterns in early medieval Europe using ancient DNA.

bioRxiv · Mar 15, 2024 · PreprintEvolutionary Biology

A disease-associated gene desert orchestrates macrophage inflammatory responses via ETS2

C. T. Stankey, C. Bourges, T. Turner-Stokes, A. P. Piedade, C. Palmer-Jones, I. Papa, M. Silva dos Santos, L. O. Randzavola, L. Speidel, E. C. Parkes, W. Edwards, A. P. Rochford, C. Murray, J. I. MacRae, P. Skoglund, , J. C. Lee

The paper identifies ETS2 as a master regulator of macrophage inflammatory responses linked to a disease-associated gene desert and shows how modulating this pathway could improve treatment of inflammatory diseases.

bioRxiv · May 5, 2023Immunology

The Selection Landscape and Genetic Legacy of Ancient Eurasians

E. K. Irving-Pease, A. Refoyo-Martinez, W. Barrie, A. Ingason, A. Pearson, A. Fischer, K.-G. Sjögren, A. S. Halgren, R. Macleod, F. Demeter, R. A. Henriksen, T. Vimala, H. McColl, A. Vaughn, L. Speidel, , E. Willerslev

This study models ancient Eurasian selection landscapes and shows ancestry-specific genetic risk associations with modern phenotypes.

bioRxiv · Sep 22, 2022Evolutionary Biology

Balancing selection on genomic deletion polymorphisms in humans

A. Aqil, L. Speidel, P. Pavlidis, O. Gokcumen

The paper identifies 63 ancient deletion polymorphisms in humans associated with GWAS traits and shows they likely evolved under balancing selection.

bioRxiv · Apr 28, 2022Evolutionary Biology