M. Silva dos Santos

The paper identifies ETS2 as a master regulator of macrophage inflammatory responses linked to a disease-associated gene desert and shows how modulating this pathway could improve treatment of inflammatory diseases.

This study identifies GOT1 as a key factor in priming cells for hypoxic adaptation by enhancing glycolysis and HIF1α stabilization before full HIF1 activation.

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

This study shows that diet can suppress glioblastoma by restoring quiescence in p53-deficient neural stem cells through omega-3 fatty acids.

This study introduces 13C-dynamods to quantify the turnover of modified ribonucleosides in RNA, revealing distinct kinetic behaviors of m6A and m7G and their responses to stress conditions.

The paper designs and characterizes MOG analogues to study MCT2 pharmacophore, KG biology, and cellular effects of NOG, showing compounds that inhibit PHDs without cytotoxicity.

This study shows that nitisinone can kill tsetse flies without harming bees, offering an eco-friendly method to control African trypanosomiasis transmission.