J. C. Lee

A disease-associated gene desert orchestrates macrophage inflammatory responses via ETS2

The paper identifies ETS2 as a master regulator of macrophage inflammatory responses linked to a disease-associated gene desert and shows how modulating this pathway could improve treatment of inflammatory diseases.

Prediction error determines how memories are organized in the brain: a study of Pavlovian fear extinction in rats

This study shows that gradual extinction, which produces small prediction errors, is more effective than standard extinction in long-term fear suppression in rats, supporting latent state theories of memory organization.

Endothelial stiffening induced by CD36-mediated lipid uptake leads to endothelial barrier disruption and contributes to atherosclerotic lesions

This study shows that CD36-mediated lipid uptake causes endothelial stiffening, leading to barrier disruption and atherosclerosis in mouse models, with sex-dependent effects.

Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 ℃

The paper shows ice nucleation proteins self-assemble into fibres that trigger freezing near 0 ℃ by forming multimers essential for frost formation.

Beclin1 is essential for intestinal homeostasis.

This study shows BECLIN1 is critical for intestinal homeostasis, as its deletion in adult mice causes fatal enteritis with compromised gut barrier integrity and morphological abnormalities.

Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

Staphylococcus aureus delta toxin modulates both extracellular membrane vesicle biogenesis and amyloid formation

This study shows that Staphylococcus aureus delta toxin promotes both extracellular membrane vesicle biogenesis and amyloid fibril formation in vitro, but amyloids are not detected in vivo despite MVs being present.

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.

Physiological state matching in a pair bonded poison frog

The paper investigates emotional contagion in poison frogs, finding physiological state-matching between male and female partners, independent of behavioral or reproductive factors.

Beta-Catenin Limits Osteogenesis on Regenerative Materials in a Stiffness-Dependent Manner

This study shows that beta-catenin limits osteogenesis on stiff nanoparticulate mineralized collagen glycosaminoglycan scaffolds by modulating Wnt and mechanotransduction pathways.

A Functional Menadione Biosynthesis Pathway is Required for Capsule Production by Staphylococcus aureus.

This study identifies menD as a regulator of capsule production in S. aureus through GWAS and functional validation, showing its role in gentamicin resistance without major growth defects.

Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease

This study identifies distinct genetic and immunologic features of recurrent stage I lung adenocarcinoma using multiomic profiling and single-cell RNA-seq.

Genetically Engineered Strains for Combinatorial Cardiovascular Optobiology

The paper introduces 21 genetically engineered mouse lines for combinatorial optogenetic studies in cardiovascular biology, enabling biallelic combination of effectors and sensors in multiple cell types.

Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics

This paper introduces a deep learning method to improve high-content screening for Alzheimer's disease therapeutics by generating predicted fluorescent signals from alternative markers.

Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling

This study shows that increasing stiffness of MC-GAG scaffolds enhances osteogenesis through YAP/TAZ and Wnt signaling, while BMPR signaling is independent of mechanical cues.

The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

This study shows that the Firre locus produces a trans-acting RNA involved in hematopoiesis and immune function, as demonstrated through genetic models and functional assays.

Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus

This paper investigates the regulation of capsular polysaccharide biosynthesis in Staphylococcus aureus, identifying key regulatory elements and showing how SigB and repressors control gene expression patterns.

The biogenesis of extracellular vesicles from Staphylococcus aureus and their application as a novel vaccine platform

This study identifies mechanisms of extracellular vesicle (EV) biogenesis in Staphylococcus aureus and demonstrates their potential as a vaccine platform through engineered EVs.