J. I. MacRae

A disease-associated gene desert orchestrates macrophage inflammatory responses via ETS2

The paper identifies ETS2 as a master regulator of macrophage inflammatory responses linked to a disease-associated gene desert and shows how modulating this pathway could improve treatment of inflammatory diseases.

Asparagine availability controls B cell homeostasis

The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.

A malaria parasite phospholipase facilitates efficient asexual blood stage egress

This study identifies LCAT as a key enzyme required for efficient egress of malaria parasites from red blood cells during the asexual blood stage.

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

This study identifies PfGDPD as a choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in Plasmodium falciparum.

T cell migration requires ion and water influx to regulate actin polymerization

This study shows that chemokine-induced T cell migration requires water entry at the leading edge to facilitate actin polymerization.

Diet suppresses tumour initiation by maintaining quiescence of mutation-bearing neural stem cells

This study shows that diet can suppress glioblastoma by restoring quiescence in p53-deficient neural stem cells through omega-3 fatty acids.

Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling

This study introduces 13C-dynamods to quantify the turnover of modified ribonucleosides in RNA, revealing distinct kinetic behaviors of m6A and m7G and their responses to stress conditions.

Novel MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

The paper designs and characterizes MOG analogues to study MCT2 pharmacophore, KG biology, and cellular effects of NOG, showing compounds that inhibit PHDs without cytotoxicity.

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

This study shows that nitisinone can kill tsetse flies without harming bees, offering an eco-friendly method to control African trypanosomiasis transmission.

Identifying strategies to target the metabolic flexibility of tumours.

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

Cryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues

This paper introduces Cryo-OrbiSIMS, a cryogenic workflow that improves detection of semi-volatile molecules in tissues, revealing new localization patterns and enabling integration with genetic analysis.

Delineating the rules for structural adaptation of membrane-associated proteins to evolutionary changes in membrane lipidome

The paper investigates how changes in membrane lipid composition drive structural adaptations in membrane-associated proteins across two fission yeast species.