β-Lapachone Regulates Mammalian Inositol Pyrophosphate Levels in an NQO1- and Oxygen-dependent Manner
V. B. Eisenbeis, D. Qiu, L. Strotmann, G. Liu, I. Prucker, K. Ritter, C. Loenarz, A. Saiardi, H. J. Jessen
This study shows β-lapachone reduces inositol pyrophosphate levels in mammalian cells through NQO1-dependent oxygen activation and ROS production.
bioRxiv · Nov 27, 2022Biochemistry