H. J. Jessen

Conservation of heat stress acclimation by the inositol polyphosphate multikinase, IPMK responsible for 4/6-InsP7 production in land plants

This study identifies IPMK as the enzyme responsible for producing 4/6-InsP7 in land plants and shows its role in heat stress acclimation through regulation of HSF transcription activity.

Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in Arabidopsis thaliana Chloroplasts Through Specific RelA/SpoT Homologs

This study uses CE-MS to measure (p)ppGpp levels in Arabidopsis thaliana during infection, showing increased ppGpp via RSH2/RSH3 and PAMP signaling.

Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

This study uses Drosophila to investigate polyphosphate (polyP) functions, revealing its role in hemolymph clotting and developmental timing, with implications for mammalian systems.

Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81

The paper shows that 1,5-IP8 decline triggers the yeast PHO starvation response by inactivating Pho81 through its SPX domain, revealing a unified model of phosphate signaling across eukaryotes.

β-Lapachone Regulates Mammalian Inositol Pyrophosphate Levels in an NQO1- and Oxygen-dependent Manner

This study shows β-lapachone reduces inositol pyrophosphate levels in mammalian cells through NQO1-dependent oxygen activation and ROS production.

Metabolic consequences of polyphosphate synthesis and imminent phosphate limitation

This study investigates how polyphosphate synthesis and phosphate limitation affect yeast metabolism, revealing that polyphosphate serves metabolic roles beyond phosphate storage.

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

This study identifies Arabidopsis PFA-DSP proteins as specific inositol pyrophosphate phosphohydrolases, revealing their role in regulating these signaling molecules.

Photoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes

The paper identifies Magic Spot Nucleotide interactomes in E. coli and S. typhimurium using photoaffinity capture compounds, revealing new targets like ApaH.

Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry (CE-ESI-MS)

This paper develops a CE-ESI-MS method to analyze inositol phosphates and pyrophosphates, revealing unknown synthesis pathways in mammals.

ITPK1 is an InsP6/ADP phosphotransferase that controls systemic phosphate homeostasis in Arabidopsis

This study shows ITPK1 generates PP-InsPs from InsP6 and regulates phosphate homeostasis in Arabidopsis by controlling InsP7 and InsP8 synthesis.

ITPK1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis thaliana

This study shows that ITPK1 produces 5-InsP7, which binds to auxin receptors and influences plant growth responses.

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis.

This study identifies VIH1 and VIH2 as bifunctional enzymes regulating phosphate homeostasis in Arabidopsis by modulating PP-InsP levels in response to ATP concentration changes.