A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia
O. Lancho, A. Singh, V. da Silva-Diz, L. Tottone, P. Renck Nunes, M. Aleksandrova, J. Khatun, S. Luo, C. Zhao, H. Zheng, E. Chiles, Z. Zuo, P. P. Rocha, X. Su, H. Khiabanian, D. Herranz
This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.
bioRxiv · May 21, 2022Cancer Biology