Author

V. da Silva-Diz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Herranz· 3 shared O. Lancho· 3 shared X. Su· 3 shared A. Singh· 2 shared E. Chiles· 2 shared M. Aleksandrova· 2 shared S. Luo· 2 shared A. Alasadi· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

D. Herranz

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3 papers

Recent·Most cited

Therapeutic targeting of ACLY in T-ALL in vivo

V. da Silva-Diz, A. Singh, M. Aleksandrova, O. Kim, C. Thai, O. Lancho, P. R. Nunes, H. Affronti, X. Su, K. Wellen, D. Herranz

This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.

bioRxiv · Mar 27, 2023Cancer Biology

A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

O. Lancho, A. Singh, V. da Silva-Diz, L. Tottone, P. Renck Nunes, M. Aleksandrova, J. Khatun, S. Luo, C. Zhao, H. Zheng, E. Chiles, Z. Zuo, P. P. Rocha, X. Su, H. Khiabanian, D. Herranz

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

bioRxiv · May 21, 2022Cancer Biology

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

V. da Silva-Diz, B. Cao, O. Lancho, E. Chiles, A. Alasadi, S. Luo, D. Augeri, S. Minuzzo, S. Indraccolo, X. Su, S. Jin, D. Herranz

This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.

bioRxiv · Jun 23, 2020Cancer Biology