H. Zheng

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

Dynamic Tracking of Native Precursors in Adult Mice

The paper develops a method to quantify hematopoietic precursors in mice, showing their contribution to both normal and perturbed hematopoiesis, and applies it to a Fanconi Anemia model.

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

SlWRKY80 recruits SlHDA1 to regulates the tomato fruit ripening and color transformation

This study identifies SlWRKY80's role in tomato fruit ripening and color change by regulating SlSGR1 and SlPSY1 through recruitment of SlHDA1.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

The Legionella collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans

This study determines the crystal structure of Legionella collagen-like protein and reveals its unique binding mechanism for sulphated glycosaminoglycans.

Molecular Forecasting of Domoic Acid during a Pervasive Toxic Diatom Bloom

The paper identifies molecular predictors of domoic acid production during a harmful algal bloom and links iron and silica co-limitation to bloom dynamics and toxicity.

High Resolution Biological and Physical Sampling Reveals Expression of Domoic Acid Biosynthetic Genes at Frontal Zones

This study combines high-resolution physical and multi-omic sampling to identify DA biosynthetic gene expression in frontal zones of Monterey Bay during declining upwelling.

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

Quantitative Profiling of Lysosomal pH Heterogeneity using Fluorescence Lifetime Imaging Microscopy

This paper introduces a FLIM-based method to quantitatively analyze lysosomal pH heterogeneity in mammalian cells and C. elegans, revealing pH differences and dynamics without transgenic reporters.

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

Tafazzin Mediates Tamoxifen Resistance by Regulating Cellular Phospholipid Composition in ER-Positive Breast Cancer

This study identifies Tafazzin's role in tamoxifen resistance by regulating phospholipid composition in ER+ breast cancer cells, showing that TAZ depletion promotes resistance via an LPC-LPA axis.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Proteomic analysis revealed the function of PoElp3 in development, pathogenicity, and autophagy through the tRNA-mediated translation efficiency in the rice blast fungus

Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP

This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.

Circulating Sex-specific Markers of Plaque Instability in Women and Men with Severe Carotid Atherosclerosis

This study identifies sex-specific circulating markers of plaque instability in men and women with severe carotid atherosclerosis, showing differences in immune and lipid profiles between sexes.

CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptor

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Massive expansion of the pig gut virome based on global metagenomic mining

This study establishes the Pig Virome Database (PVD) by mining global metagenomic data, revealing extensive viral diversity and functional potential in the pig gut.

Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum

This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

CALCIUM-DEPENDENT PROTEIN KINASE32 regulates cellulose biosynthesis through post-translational modification of cellulose synthase

The paper identifies CPK32 as a kinase that phosphorylates CESA3, affecting CSC motility and stability, thereby regulating cellulose biosynthesis.

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer

This study develops an extracellular vesicle-based test to detect early-stage high-grade serous ovarian cancer with high sensitivity and specificity using markers identified from murine models and validated in a human pilot study.

Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees

The paper shows engineered symbiotic bacteria can inhibit microsporidia infection in honeybees by delivering RNAi targeting the parasite's redox system.

Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.