Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections
J. H. van Puffelen, B. Novakovic, L. van Emst, D. Kooper, T. C. M. Zuiverloon, U. T. H. Oldenhof, J. A. Witjes, T. E. Galesloot, A. Vrieling, K. K. H. Aben, L. A. L. M. Kiemeney, E. Oosterwijk, M. G. Netea, J. L. Boormans, A. G. van der Heijden, , S. H. Vermeulen
This study shows that intravesical BCG therapy in NMIBC patients induces trained immunity, reduces respiratory infections, and links germline variation to treatment outcomes.
bioRxiv · Feb 21, 2022Immunology