M. G. Netea

Fatty acid desaturation and lipoxygenase pathways support trained immunity

This study identifies fatty acid desaturation and lipoxygenase pathways as essential for BCG-induced trained immunity in human monocytes.

MMR vaccination induces a trained immunity program characterized by functional and metabolic reprogramming of γδ T cells

MMR vaccination induces functional and metabolic reprogramming of γδ T cells, enhancing their activation and cytokine production.

Diversity and ecology of Caudoviricetes phages with genome terminal repeats in fecal metagenomes from four Dutch cohorts

The paper identifies and characterizes Caudoviricetes phages with genome terminal repeats in fecal metagenomes, finding 1,899 species-level units and 34 associations between phages and human phenotypes.

Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemic

The paper compares anti-viral immune responses between individuals of Indian and European origin, finding differences in chromatin accessibility and transcriptional responses to viral stimulation, which may explain variations in COVID-19 susceptibility.

Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

The paper compares the inflammatory proteome of Tanzanian and Dutch adults, finding a pro-inflammatory phenotype in Tanzanians linked to dietary factors and metabolic regulators.

Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections

This study shows that intravesical BCG therapy in NMIBC patients induces trained immunity, reduces respiratory infections, and links germline variation to treatment outcomes.

Differential recognition and cytokine induction by the peptidorhamnomannan from Sporothrix brasiliensis and S. schenckii

This study compares immune responses to PRM from S. brasiliensis and S. schenckii, showing differential cytokine induction and receptor involvement.

Discovery, diversity and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts

The paper discovers new crAss-like phage species and explores their diversity, genomic features, host associations, and links to human health phenotypes in Dutch gut metagenomes.

Gut microbial structural variations as determinants of human bile acid metabolism

The paper identifies bacterial structural variants associated with bile acid metabolism in humans using metagenomic data from two Dutch cohorts.

Heme induces innate immunity memory

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.