Pharmacology & ToxicologybioRxiv
A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques
J. Su, S. M. Simpson, S. Sung…·P. F. Kiser
This study evaluates a subcutaneous TAF implant for HIV prevention, finding it achieves sustained drug levels but causes severe local inflammation and necrosis in rabbits and macaques.
DOI 10.1128/aac.01893-19