A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques
J. Su, S. M. Simpson, S. Sung, E. Bryndza-Tfaily, R. S. Veazey, M. A. Marzinke, J. Qiu, D. Watrous, L. Widanapathirana, E. Pearson, M. M. Peet, D. Karunakaran, B. Grasperge, G. Dobek, C. M. Cain, , P. F. Kiser
This study evaluates a subcutaneous TAF implant for HIV prevention, finding it achieves sustained drug levels but causes severe local inflammation and necrosis in rabbits and macaques.
bioRxiv · Sep 19, 2019Pharmacology & Toxicology