HIV-1 Vpr Degrades TET2 to Suppress IRF7 and Interferon Expression in Plasmacytoid Dendritic Cells
L. Su, Q. Wang, L.-c. Tsao, L. Lv, Y. Xiong, L. Cheng, H. Yu, L. Zhang
This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.
bioRxiv · Oct 30, 2019 · PreprintImmunology