Y. Xiong

Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector

This study examines immune gene expression in African snails exposed to Schistosoma mansoni and evaluates diet effects on gene expression.

Bioluminescence Imaging of Potassium Ion Using a Sensory Luciferin and an Engineered Luciferase

This paper develops a bioluminescent indicator for potassium ions using a modified luciferin and engineered luciferase, validated in cell lines, neurons, and live mice.

Discovery of the First-in-class G9a/GLP PROTAC Degrader

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

Differences in milk microbiota between healthy cows and cows with recurring Klebsiella mastitis

The paper compares milk microbiota between healthy cows and those with recurring Klebsiella mastitis, finding differences in bacterial genera associated with infection.

PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

This study identifies PI3Kγ as a regulator of neutrophil extracellular trap formation in abdominal aortic aneurysm via noncanonical pyroptosis, showing its inhibition reduces inflammation and ameliorates AAA.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

This study shows that USP7 inhibition accelerates osseointegration in senile osteoporotic mice by enhancing macrophage efferocytosis and inducing apoptosis in aged BMSCs.

Diet-induced obesity results in endothelial cell desensitization to VEGF-A and permanent islet vascular dysfunction

This study shows that diet-induced obesity causes permanent vascular dysfunction in pancreatic islets by desensitizing endothelial cells to VEGF-A, impairing glucose homeostasis.

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent

The study shows that HDAC6's role in inflammasome formation varies depending on the cellular context and model system used.

LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation

This study shows that LRRK2 G2019S promotes colon cancer by enhancing intestinal inflammation and tumor growth in mice.

Alterations in the Mammary Gland and Tumor Microenvironment of Formerly Obese Mice

This study shows that weight loss in formerly obese mice reduces mammary gland inflammation and fibrosis but does not fully resolve collagen deposition in tumors, suggesting partial microenvironmental recovery.

Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

This study compares the biochemical and biological potencies of three EP300/CREBBP acetyltransferase inhibitors and demonstrates their utility in investigating epigenetic mechanisms.

Designer DNA NanoGripper

The paper designs, synthesizes, and characterizes a DNA nanorobot, NanoGripper, capable of capturing viral particles and functioning as a biosensor for SARS-CoV-2 detection in human saliva.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens - a step closer to a broad orthopoxvirus vaccine

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

Development, Characterization, and Structural Analysis of a Genetically Encoded Red Fluorescent Peroxynitrite Biosensor

The paper develops a red fluorescent peroxynitrite biosensor (pnRFP) using a genetically encoded boronic acid-containing amino acid, characterizes its properties, and elucidates its sensing mechanism through structural analysis.

Vascular Smooth Muscle Cell Mechanotransduction Through Serum and Glucocorticoid Inducible Kinase-1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension

This study shows that SGK-1 in vascular smooth muscle cells promotes IL-6 and macrophage accumulation in hypertension via mechanotransduction and AngII signaling.

Inhibiting Bet1-mediated transport of MMP14 to plasma membrane impaired GBM cell invasion

This study shows BET1 promotes GBM cell invasion by transporting MMP14 to the plasma membrane, suggesting BET1 as a potential therapeutic target.

T492I mutation alters SARS-CoV-2 properties via modulating viral non-structural proteins

The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.

Target Recycling Amplification Process for Digital Detection of Exosomal MicroRNAs Through Photonic Resonator Absorption Microscopy

This paper introduces TRAP, a method for detecting exosomal miRNAs with high sensitivity and selectivity, showing improved detection limits compared to qRT-PCR.

Photonic-Plasmonic Coupling Enhanced Fluorescence Enabling Digital-Resolution Ultrasensitive Protein Detection

This paper enhances fluorescence detection using photonic-plasmonic coupling, achieving ultrasensitive protein detection with a 52-fold signal boost and 10 fg/ml detection limit.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Novel leaf-root coordination driven by leaf water storage tissues in mangroves

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

Comprehensively characterizing evolutionarily conserved differential dosage compensations of the X chromosome during development and in diseases

The paper identifies two X gene groups with distinct dosage compensations during development and in diseases, and discovers new regulators of X dosage compensation.

In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors in the dark and mediates recovery of the cone photoresponse in response to forskolin

Abl2 mediates microtubule nucleation and repair via tubulin co-condensation.

This study identifies Abl2's role in microtubule nucleation and repair through tubulin co-condensation and direct interactions.