Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
L.-h. Zhao, Q. Yuan, A. Dai, C.-W. Chen, X. He, C. Zhang, Y. Xu, Y. Zhou, M.-W. Wang, D. Yang, H. E. Xu
The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.
bioRxiv · Oct 9, 2022 · PreprintBiochemistry