Author

M.-W. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 6 Research Focus:protein structure prediction· 5 Assay:cryo-EM· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:structural biology· 2

Frequent Co-Authors

D. Yang· 8 shared H. E. Xu· 7 shared A. Dai· 5 shared Y. Jiang· 5 shared C. Ye· 4 shared F. Zhou· 4 shared W. Yin· 4 shared Q. Zhou· 3 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersBiophysics

D. Yang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The force-sensing GPCR LPHN2 is indispensable for normal auditory function

Z. Yang, M.-W. Wang, S.-H. Zhou, Z.-c. Song, K.-K. Zhu, X. Wen, Q.-Y. Zhang, Y. Guan, J.-R. Gao, X.-H. Wang, Y.-Q. Wang, W.-W. Liu, L. Xu, W. Xiong, R. Chai, , J.-P. Sun

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

bioRxiv · Oct 24, 2023 · PreprintPhysiology

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1

L.-h. Zhao, Q. Yuan, A. Dai, C.-W. Chen, X. He, C. Zhang, Y. Xu, Y. Zhou, M.-W. Wang, D. Yang, H. E. Xu

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

bioRxiv · Oct 9, 2022 · PreprintBiochemistry

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

S. Ma, Y. Chen, A. Dai, W. Yin, J. Guo, D. Yang, F. Zhou, Y. Jiang, M.-W. Wang, H. E. Xu

The paper presents cryo-EM structures of MC1R-Gs complexes with ligands, revealing calcium's role in hormone recognition and Gβ interactions, and a conserved activation mechanism.

bioRxiv · Jun 20, 2021Biophysics

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

X. Wang, X. Cheng, L. Zhao, Y. Wang, C. Ye, X. Zou, A. Dai, Z. Cong, J. Chen, Q. Zhou, T. Xia, H. Jiang, H. E. Xu, D. Yang, M.-W. Wang

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

bioRxiv · Jun 9, 2021Biochemistry

Molecular basis for kinin selectivity and activation of the human bradykinin receptors

Y.-L. Yin, C. Ye, F. Zhou, J. Wang, D. Yang, W. Yin, M.-W. Wang, H. E. Xu, Y. Jiang

The paper reports structures of bradykinin receptors bound to their ligands and reveals mechanisms of selectivity and activation, providing insights for drug design.

bioRxiv · May 27, 2021Biophysics

Structures of the human cholecystokinin receptors in complex with agonists and antagonists

X. Zhang, C. He, M. Wang, Q. zhou, D. Yang, Y. Zhu, W. Feng, H. Zhang, A. Dai, X. Chu, J. Wang, Z. Yang, Y. Jiang, U. Sensfuss, Q. Tan, , Q. Zhao

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

bioRxiv · May 19, 2021 · PreprintBiophysics

Structural basis for ligand recognition and G protein-coupling promiscuity of the cholecystokinin A receptor

Q. Liu, D. Yang, Y. Zhuang, T. I. Croll, X. Cai, A. Dai, X. He, J. Duan, W. Yin, C. Ye, F. Zhou, B. Wu, Q. Zhao, H. E. Xu, M.-W. Wang, Y. Jiang

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

bioRxiv · May 9, 2021 · PreprintBiophysics

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

Y. Jiang, F. Zhou, C. Ye, X. Ma, W. Yin, Q. Zhou, X. He, X. Zhang, T. I. Croll, D. Yang, P. Wang, H. E. Xu, M.-W. Wang

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

Cell Research · Mar 19, 2021Peer-reviewedBiophysics

A novel G protein-biased and subtype selective agonist for a G protein-coupled receptor discovered from screening herbal extracts

B. Zhang, S. Zhao, D. Yang, Y. Wu, Y. Xin, H. Cao, X.-P. Huang, X. Cai, W. Sun, N. Ye, Y. Xu, Y. Peng, S. Zhao, Z.-J. Liu, G. Zhong, , W. Shui

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

bioRxiv · Dec 22, 2019Biochemistry