Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations
D. Zemmour, L.-M. Charbonnier, J. Leon, E. Six, S. Keles, M. Delville, S. Baris, J. Zuber, K. Chen, B. Neven, M. I. Garcia-Lloret, F. Ruemmele, C. B. Brugnara, N. Cerf-Bensussan, F. Rieux-Laucat, , C. Benoist
The paper analyzes FOXP3 deficiencies in humans and mice using single-cell RNA-seq and flow cytometry to uncover intrinsic and extrinsic CD4+ T cell perturbations in IPEX syndrome.
bioRxiv · Jul 6, 2020Immunology