J. Zuber

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to Navitoclax

This study identifies GLIS2 as a driver of pediatric AMKL and shows its sensitivity to navitoclax, offering a potential therapeutic strategy.

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

This study identifies HUWE1 as a regulator of TTP proteasomal degradation by controlling its phosphorylation, distinct from MAPK-mediated phosphorylation.

RNA Helix Thermodynamics: The End Game

The paper updates RNA helix thermodynamic parameters by incorporating sequence-dependent terminal penalties, improving prediction accuracy for helix stability.

CD28 costimulatory domain protects against tonic signaling-induced functional impairment in CAR-Tregs

This study compares CD28 and 4-1BB costimulatory domains in CAR-Tregs, finding CD28 better preserves function and survival under tonic signaling.

Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

The paper analyzes FOXP3 deficiencies in humans and mice using single-cell RNA-seq and flow cytometry to uncover intrinsic and extrinsic CD4+ T cell perturbations in IPEX syndrome.

Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter

The paper shows that CBF fusions in AML activate the PU.1 antisense promoter, reducing sense PU.1 transcription and blocking myeloid differentiation, similar to T-cell differentiation.

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.