C. Benoist

FoxP3 recognizes microsatellites and bridges DNA through multimerization

This study shows FoxP3 forms multimers to bridge DNA through TnG repeats, revealing a new DNA recognition mechanism involving microsatellites.

An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity

The paper defines the Treg regulatory network using single-cell chromatin accessibility and machine learning, revealing FoxP3's limited role in shaping Treg diversity.

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

The paper investigates relationships between colon T regulatory cell subsets, finding that their phenotypes are influenced by tissue-specific cues rather than their differentiation origin.

Microbiome induced complement synthesized in the gut protects against enteric infections

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

A dynamic atlas of immunocyte migration from the gut

The paper maps immunocyte migration from the gut using single-cell genomics and a photoconvertible mouse model, showing lineage-specific emigration patterns and their influence on peripheral immunity.

FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis

This study shows FoxP3 can form two dimerization states, with head-to-head dimerization supporting function and swap-dimerization impairing it.

FoxP3 associates with enhancer-promoter loopsto regulate Treg-specific gene expression

This study identifies FoxP3's role in Treg cell identity by showing its association with enhancer-promoter loops and its correlation with heightened enhancer-promoter cross-talk.

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

The paper investigates SARS-CoV2-induced inflammatory responses in monocytes using in vitro co-cultures, identifying a virus-specific gene cluster distinct from other viruses.

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.

Profound Treg perturbations correlate with COVID-19 severity

The paper identifies Treg cell perturbations in severe COVID-19 patients, showing increased FoxP3 levels and pro-inflammatory traits linked to disease severity.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

The paper analyzes FOXP3 deficiencies in humans and mice using single-cell RNA-seq and flow cytometry to uncover intrinsic and extrinsic CD4+ T cell perturbations in IPEX syndrome.

A single droplet digital PCR for ESR1 activating mutations detection in plasma

This paper develops a multiplex droplet digital PCR assay for detecting ESR1 activating mutations in plasma, showing high sensitivity and concordance with NGS data.