Di-codon organization links tRNA modifications to cancer cell proteome composition
Kiana Hosseinpour Moghaddam, Clelia Timpone, Laasya N. Gowda, Candani A Tutuka, Gail Petuna Risbridger, Joel R. Steele, Ralf B. Schittenhelm, Eric P. Kusnadi, Luc Furic, Ola Segnestam Larsson
The paper shows ELP3 modifies tRNA at U34 and regulates proteome composition through specific di-codon pairs, affecting cancer cell proliferation.
bioRxiv · Mar 12, 2026 · PreprintMolecular Biology