Joel R. Steele

Stress unmasks impaired endocrine coordination of glucose metabolism in dystrophin deficiency

This study shows that stress reveals impaired endocrine coordination of glucose metabolism in dystrophin deficiency, with interventions improving glucose control and muscle function.

Monocyte Migration Emerges from a Divergent Chemokine Signaling Network

The paper maps the chemokine-stimulated signal transduction network in monocytic cells and shows that chemotaxis emerges from a divergent signaling network that can be inhibited to block cell migration.

Di-codon organization links tRNA modifications to cancer cell proteome composition

The paper shows ELP3 modifies tRNA at U34 and regulates proteome composition through specific di-codon pairs, affecting cancer cell proliferation.

If the shoe fits? -- technical nuances of plasma proteomic workflows in clinical and preclinical contexts

The paper benchmarks plasma proteomic workflows across species and methods, showing workflow choice significantly impacts detected proteins and depth.

Haptoglobin and glutamine synthetase may biomark cachexia induced by anti-acute myeloid leukemia chemotherapy

This study shows that the AML chemotherapy regimen induces cachexia in mice, characterized by body and lean mass loss, and identifies haptoglobin as a potential biomarker for chemotherapy-induced cachexia.

Analysis and visualization of quantitative proteomics data using FragPipe-Analyst

FragPipe-Analyst provides an R shiny web server and R package for downstream analysis and visualization of quantitative proteomics data from FragPipe.

Hypoxic injury triggers maladaptive repair in human kidney organoids

This study uses human kidney organoids to model hypoxic injury and maladaptive repair, identifying molecular and metabolic changes associated with AKI and CKD progression.

Systems-level investigation of mucopolysaccharidosis IIIA identifies deficient synaptic activity as a key driver of disease progression

The paper uses a zebrafish model of MPS IIIA to identify synaptic activity deficiencies as a key driver of disease progression through systems-level omics analyses and a novel bioinformatic tool.