Ola Segnestam Larsson

RAPPL-Seq enables rapid, high-sensitivity ribosome profiling of scarce samples by improving RPF recovery efficiency and reducing processing time.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

The paper shows ELP3 modifies tRNA at U34 and regulates proteome composition through specific di-codon pairs, affecting cancer cell proliferation.

This study identifies novel tRNA modifications in Plasmodium falciparum using an optimized sequencing protocol, revealing dynamic changes during development and stress.

This study shows that TSC2 loss in neural progenitor cells suppresses translation of ASD/NDD-associated transcripts, which can be reversed by inhibiting mTORC1 or MNK1/2.

This study shows SLC25A46 is required for stress-induced mitochondrial hyperfusion and involved in mitochondrial cholesterol homeostasis.

The paper identifies start-stop elements in 5' UTRs that repress translation by halting ribosomes, showing their prevalence in human genes and impact on cellular processes.

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.

The paper introduces anota2seq, an algorithm for analyzing translational efficiency from ribosome or polysome profiling data, revealing translational buffering and mTOR-dependent gene regulation.

NOMAD is an R package that provides an efficient ANOVA-based normalization method for iTRAQ MS data to reduce MS run bias and enable valid cross-run comparisons.

This paper presents an optimized non-linear sucrose gradient method for polysome-profiling that reduces sample handling and enables translatome analysis from small tissue samples and primary cells.