Luc Furic

This paper identifies a synergistic combination of RNA Polymerase I inhibitor CX-5461 and CDK inhibitor Dinaciclib that enhances therapeutic efficacy in AML by inducing nucleolar stress and cell cycle arrest.

This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.

The paper shows ELP3 modifies tRNA at U34 and regulates proteome composition through specific di-codon pairs, affecting cancer cell proliferation.

This study shows PMR-116, a second-generation RiBi inhibitor, effectively targets high-MYC cancers without causing DNA damage, suggesting RiBi as a viable cancer therapy.

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.

The paper introduces anota2seq, an algorithm for analyzing translational efficiency from ribosome or polysome profiling data, revealing translational buffering and mTOR-dependent gene regulation.