C9orf72-derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons
Paolo M. Marchi, Lara Marrone, Laurent Brasseur, Luc Bousset, Christopher P Webster, Marco Destro, Emma F. Smith, Christa G Walther, Victor Alfred, Raffaele Marroccella, Darren A. Robinson, Allan Christian Shaw, Lai Mei Wan, Andrew J. Grierson, Stephen J. Ebbens, , Mimoun Azzouz
This study shows poly-GA DPRs are taken up by astrocytes via endocytosis, spread to motor neurons, and cause axonal swellings through lysosomal dysfunction.
bioRxiv · Oct 11, 2021 · PreprintNeuroscience