Modulating Cardiac-Gut Microbiome Interaction Post-Myocardial Infarction with Engineered Bacteria
Tushar Madaan, Michelle L. Nieman, Tushar Rakheja, Nabil Siddiqui, Dominick Gherardini, Mathieu G. Sertorio, Nitin S. Kamble, Shindu C. Thomas, Alexandra Hartman, Sheryl E. Koch, Lance Knipper, Vito A. Marino, Sakthivel Sadayappan, John N. Lorenz, John P. Konhilas, Nalinikanth Kotagiri
This study shows engineered bacteria can improve survival and cardiac function after myocardial infarction by enhancing gut barrier integrity and reducing inflammation.
bioRxiv · Jul 10, 2025 · PreprintSynthetic Biology