Sheryl E. Koch

Sex-Dependent Epigenomic and Transcriptomic Reprogramming Links Maternal Obesity to Cardiac Remodeling in Adult Offspring

This study shows maternal obesity causes sex-dependent epigenetic and transcriptomic changes in offspring hearts, leading to sex-specific cardiac remodeling and disease risk.

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

Modulating Cardiac-Gut Microbiome Interaction Post-Myocardial Infarction with Engineered Bacteria

This study shows engineered bacteria can improve survival and cardiac function after myocardial infarction by enhancing gut barrier integrity and reducing inflammation.