Systematic modeling of phenotypic drug response profiles inpatient-derived organoids
Seungil Kim, Einar Bjarki Gunnarsson, Michael E. Doche, Yuyuan Zhou, Yukai Huang, Scott Valena, Pratiksha Kshetri, Elizabeth Elton, Nolan M. Ung, Abigail Coleman, Benedikt Vilji Magnússon, Niki Torab, Lara Papasian, Brandon Choi, Eileen Fung, , Shannon M. Mumenthaler
The paper introduces SCOPE, a method using AI and time-lapse imaging to classify drug responses in organoids into four phenotypic groups, identifying new drug effects and therapeutic uses.
bioRxiv · Jul 31, 2026 · PreprintBioengineering