Progressive neuroinflammation and deficits in motor function in a mouse model with an Epg5 pathogenic variant of Vici syndrome
Bradley T. Thornton, Alexandra G. Hardinger, Laramie Pence, Priyanka Prem Kumar, Nikolas Connolly, Scott James Weir, Jay L. Vivian
This paper describes novel Epg5 mutant mouse models of Vici syndrome, showing progressive neuroinflammation and motor deficits, and highlights the role of neuroglial activation in disease pathogenesis.
Experimental & Molecular Medicine · Jan 30, 2026Peer-reviewedGenetics