Hai‐Xi Sun

The paper uses single cell transcriptomes to study how regulatory networks change during the development of Kranz anatomy in C4 grasses.

This study establishes co-cultures of embryonic and extraembryonic stem cells to study lineage crosstalk during early mammalian development, revealing growth inhibition of pluripotent cells by extraembryonic endoderm cells.

This study introduces a gene filter denoising algorithm using optimal transport to reduce noise in spatially resolved transcriptomics data, improving clustering and cell type annotation.

This study uses a chemical cocktail to derive and culture bovine trophoblast stem cells, which retain developmental potency.

CRISPR-Detector detects, visualizes, and annotates genome-wide mutations from CRISPR/Cas gene editing events with improved speed, scalability, and accuracy.

This study analyzes cell-free DNA in COVID-19 patients to show its potential for disease monitoring and tissue injury assessment.

BDdb is a database integrating multi-omics data, cfDNA data, and biomarkers for birth defects, enabling data exploration and analysis for research and clinical applications.

The paper integrates single-cell ATAC and transcriptomic data with spatial transcriptomics to map regulatory features and disease vulnerabilities in macaque cortex.

The paper compares human and mouse neocortical development using scRNA-seq, finding differences in excitatory neuron trajectories and gene expression but conservation in glial and inhibitory neuron development.

The paper derives and characterizes XEN cells from pig embryos, showing their ability to contribute to chimerism and serve as nuclear donors for cloning.

This study introduces qCas9, a modified CRISPR/Cas9 system that enhances genome editing efficiency and reduces off-target effects in zebrafish and mammalian cells.