The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis
Jarryll A. Uy, Zahra Dargaei, Sarah Geahchan, Laura Botler, Yi Pan, Chad O. Brown, Jennifer Howe, Stephen W. Scherer, Jaideep Singh Bains, Karun Kar Singh
This study shows that SCN2A loss in human forebrain organoids impairs excitatory and inhibitory neurogenesis, leading to developmental imbalances and reversible through Sonic hedgehog inhibition.
Nature Communications · Jul 27, 2026Peer-reviewedNeuroscience