Jaideep Singh Bains

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

This study identifies recurrent inhibition as a key circuit motif regulating functional states of stress effector neurons through experimental and computational approaches.

The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis

This study shows that SCN2A loss in human forebrain organoids impairs excitatory and inhibitory neurogenesis, leading to developmental imbalances and reversible through Sonic hedgehog inhibition.

Exercise Leverages a Post-Stress Therapeutic Window in Hypothalamic CRH Neurons to Enable Recovery from Threat Sensitization

The paper shows exercise alleviates acute stress through a time-sensitive mechanism involving CRH neurons and interactions between glucocorticoids and BDNF.

Psilocybin induces sex- and context-specific recruitment of the stress axis

This study shows psilocybin activates hypothalamic stress-related neurons, with stronger effects in female mice and context-dependent changes in threat assessment.

Hypothalamic CRH neurons gate rapid social appraisal of conspecifics

This study identifies CRH neurons in the hypothalamus as critical for rapid social appraisal, showing their activity scales with social context and persists despite behavioural habituation.

Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive

This study shows that optogenetic activation of hypothalamic CRH neurons increases stress-related behaviors and reduces sucrose motivation, suggesting a role for these neurons in motivational drive.

Impact and role of hypothalamic corticotropin releasing hormone neurons in withdrawal from chronic alcohol consumption in female and male mice.

This study examines how chronic alcohol consumption affects hypothalamic CRH neurons in male and female mice during withdrawal, revealing sex-specific changes in stress responses and neuronal excitability.

Hypothalamic vasopressin sex differentiation is established during embryonic neurogenesis

The paper shows that hypothalamic vasopressin neurons are sexually dimorphic during embryonic neurogenesis, with exposure to bisphenol A causing masculinization in female brains.

Particle-Swarm Based Modelling Reveals Two Distinct Classes of CRHPVN Neurons

The paper models CRHPVN neurons using a modified AdEx model with PSO, revealing two subtypes with distinct firing dynamics and network-level roles.

Chronic Alcohol Consumption Alters Home-Cage Behaviors and Responses to Ethologically Relevant Predator Tasks in Mice

This study examines how chronic alcohol consumption affects behavior in mice during different predator threat tasks, revealing sex-specific changes in stress coping responses.

A genetically encoded fluorescent biosensor for extracellular L-lactate

This paper develops a genetically encoded fluorescent biosensor for extracellular L-lactate and demonstrates its use in imaging in cultured mammalian cells and brain tissue.

Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.

This study shows that obesity impairs astrocyte function in the orbitofrontal cortex, leading to synaptic deficits that are reversed by N-acetylcysteine.

Sex-specific vasopressin signaling buffers stress-dependent synaptic changes in female mice

The paper shows that vasopressin signaling in the PVN buffers stress-induced synaptic changes in female mice but not males.

Spatiotemporal chloride dynamics in hypothalamic CRHPVN neurons

This study investigates chloride dynamics in hypothalamic CRHPVN neurons, showing that KCC2 maintains Cl- setpoints but slows during stress, with differential regulation of inhibitory synapses.

Adaptive synaptic plasticity maintains CRH neuron output during chronic glucocorticoid exposure

The paper shows CRH neurons adapt to chronic glucocorticoid exposure by increasing synaptic strength to maintain output stability.

Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

This study investigates how ventral striatopallidal neurons modulate orexin/hypocretin neuron activity in response to food and metabolic states, revealing their role in reward-seeking behavior.

Activation of lateral hypothalamic group III mGluRs suppresses drug-seeking following abstinence and cocaine-associated increases in excitatory drive to orexin/hypocretin cells

This study shows that activating group III mGluRs in the lateral hypothalamus reduces orexin cell activity and suppresses cocaine-seeking behavior during abstinence.