Author

Chad O. Brown

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Karun Kar SinghiD· 4 shared Stephen W. SchereriD· 4 shared Jarryll A. UyiD· 3 shared Jennifer Howe· 3 shared Nadeem MurtazaiD· 3 shared Sansi Xing· 3 shared Yu Lu· 3 shared Annie A. Cheng· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Karun Kar SinghORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis

Jarryll A. Uy, Zahra Dargaei, Sarah Geahchan, Laura Botler, Yi Pan, Chad O. Brown, Jennifer Howe, Stephen W. Scherer, Jaideep Singh Bains, Karun Kar Singh

This study shows that SCN2A loss in human forebrain organoids impairs excitatory and inhibitory neurogenesis, leading to developmental imbalances and reversible through Sonic hedgehog inhibition.

Nature Communications · Jul 27, 2026Peer-reviewedNeuroscience

Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

Chad O. Brown, Jarryll A. Uy, Nadeem Murtaza, Elyse Rosa, Alexandria Alfonso, Sansi Xing, Biren M. Dave, Savannah Kilpatrick, Annie A. Cheng, Sean H. White, Jennifer Howe, Stephen W. Scherer, Yu Lu, Karun Kar Singh

This study examines how different SCN2A de novo variants affect human neuron development and function using patient-derived iPSCs.

Frontiers in Cellular Neuroscience · Jan 15, 2024Peer-reviewedNeuroscience

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

Brianna K. Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney L. Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad O. Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M. Ronen, Jennifer Howe, Aurélie Caye‐Eude, Alain Verloès, , Karun Kar Singh

This study identifies impaired OTUD7A-Ankyrin regulation as a mechanism underlying neuronal dysfunction in 15q13.3 microdeletion syndrome using mouse and human models.

Molecular Psychiatry · Jan 5, 2023Peer-reviewedNeuroscience

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies

Nadeem Murtaza, Annie A. Cheng, Chad O. Brown, Durga Praveen Meka, Shuai Hong, Jarryll A. Uy, Joelle El-Hajjar, Neta Pipko, Brianna K. Unda, Birgit Schwanke, Sansi Xing, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Brett Trost, Éric Deneault, , Karun Kar Singh

The paper maps neuron-specific protein networks of autism risk genes, identifies shared biological mechanisms, and links them to disease-relevant pathologies.

Cell Reports · Nov 1, 2022Peer-reviewedNeuroscience