Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
Andrea Loreto, Ciaran Scott Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Alberto Angeletti, Jonathan Gilley, Cristiano Lucci, Álvaro Sánchez-Martínez, Alexander J. Whitworth, Laura Conforti, Federico Dajas‐Bailador, Michael P. Coleman
This study shows mitochondrial impairment triggers Wallerian-like axon degeneration by depleting NMNAT2, activating SARM1, and replicating key steps of the Wallerian pathway in mice and flies.
Neurobiology of Disease · Nov 15, 2019Peer-reviewedNeuroscience