Andrea Loreto

This study shows that SARM1 activation causes mitochondrial dysfunction in human neurons, which can be reversed by nicotinamide or prevented by antisense oligonucleotides.

This study shows that low NMNAT2 levels cause sub-lethal SARM1 activation and reduce the effectiveness of nicotinamide riboside in axons, leading to axonal defects and behavioral changes in mice.

This paper introduces a novel mouse myelinating Schwann cell-DRG coculture system to study axon protection and degradation after injury.

The paper shows SARM1 is present in oligodendrocytes but not Schwann cells, and its deletion does not affect myelination in zebrafish or mice.

This study shows that reducing NMN levels in Drosophila prevents axon degeneration and neurodegeneration, revealing NMN's role in axon injury and disease.

This study identifies VMN, a metabolite of the pesticide vacor, as a potent SARM1 activator, showing that SARM1 removal rescues vacor-induced neuron and axon death.

This study shows mitochondrial impairment triggers Wallerian-like axon degeneration by depleting NMNAT2, activating SARM1, and replicating key steps of the Wallerian pathway in mice and flies.