Metabolic reprogramming controlled by NF-YA alternative splicing creates therapeutic opportunities in colorectal cancer
Silvia Belluti, Valentina Mularoni, Natalia Iseppato, Virginia Campani, Mirko Ronzio, Valeria Righi, Laura Cuoghi, Arianna Rinaldi, Tommaso Martinelli, Oneda Cani, Valentina Salsi, Andrea Alessandrini, Giacomo Miserocchi, Diletta Dolfini, Vincenzo Zappavigna, Carol Imbriano
This paper identifies NF-YA alternative splicing as a driver of glutamine metabolism in colorectal cancer, revealing a therapeutic target for aggressive subtypes.
bioRxiv · Mar 5, 2026 · PreprintCancer Biology