CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflicts
Laura Curti, Sara Rohban, Nicola Bianchi, Ottavio Croci, Adrian Andronache, Sara Barozzi, Michela Mattioli, Fernanda Ricci, Elena Pastori, Silvia Sberna, Simone Bellotti, Anna Accialini, Roberto Ballarino, Nicola Crosetto, Mark R. Wade, , Stefano Campaner
This study shows CDK12 prevents transcription-replication conflicts and DNA damage in MYC-overexpressing cells by repressing transcription at damaged genes.
Nature Communications · Aug 18, 2024Peer-reviewedCancer Biology