Mark R. Wade

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflicts

This study shows CDK12 prevents transcription-replication conflicts and DNA damage in MYC-overexpressing cells by repressing transcription at damaged genes.

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

This study uses phosphoproteomics to show that insulin resistance involves rewired signaling networks and widespread dysregulation of GSK3 activity.