Author

Laura E Wedlock

University of Otago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

James E. UssheriD· 2 shared Rajesh LamichhaneiD· 2 shared A Poudel· 1 shared Andrea J. VernalliD· 1 shared Chloe Tirand· 1 shared J Williams· 1 shared Meg C. Webley· 1 shared Rachel F. Hannaway· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

James E. UssherORCID

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2 papers

Recent·Most cited

IL-21 selectively augments cytotoxic potential of antigen-activated MAIT cells

Laura E Wedlock, Rajesh Lamichhane, Meg C. Webley, Selena C. L. Gilmer, Andrea J. Vernall, James E. Ussher

This study shows IL-21 enhances cytotoxicity of activated MAIT cells by increasing GrzB and perforin expression without significantly affecting cytokine production.

European Journal of Immunology · Feb 1, 2026Peer-reviewedImmunology

4-1BB expression and signaling regulates MAIT cell activation and effector functions

Rajesh Lamichhane, J Williams, Chloe Tirand, Roxanne Fouillé, Laura E Wedlock, A Poudel, Rachel F. Hannaway, James E. Ussher

This study shows that 4-1BB expression and signaling enhance MAIT cell activation and effector functions through TCR and cytokine signals.

bioRxiv · Dec 17, 2025 · PreprintImmunology