Laura Grasemann

High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping

The paper develops a high-throughput method to profile SARS-CoV-2 RBD variants' affinity against antibodies, generating binding energy landscapes for variant analysis.

Long-term protein synthesis with PURE in a mesoscale dialysis system

This study demonstrates a mesoscale dialysis system that extends protein synthesis in the PURE cell-free system to 12.5 days with a yield of 1.16 mg/mL GFP.

C2CAplus: a one-pot isothermal circle-to-circle DNA amplification system

The paper introduces C2CAplus, a one-pot isothermal DNA amplification method that improves upon C2CA by simplifying the process and increasing yield.

Improved cell-free transcription-translation reactions in microfluidic chemostats augmented with hydrogel membranes for continuous small molecule dialysis

This paper improves protein synthesis in cell-free systems using microfluidic chemostats with dialysis membranes, increasing synthesis duration and yield.