The late onset Alzheimer's disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
Georg Jocher, Stephan A. Müller, Hung‐En Hsia, Miranda Lastra Osua, Gözde Özcelik, Laura I. Hofmann, Marlene Aßfalg, Lina Dinkel, Xiao Ming Feng, Kai Schlepckow, Michael Willem, Christian Haass, Sabina Tahirović, C. P. Blobel, Stefan F. Lichtenthaler
This study identifies iRhom2 as a modifier of ADAM17-mediated TREM2 proteolysis in microglia, linking it to Alzheimer's disease risk.
Life Science Alliance · Mar 13, 2025Peer-reviewedBiochemistry