Author

Lina Dinkel

German Center for Neurodegenerative DiseasesORCID 0000-0002-5380-3152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Sabina TahirovićiD· 2 shared Stefan F. LichtenthaleriD· 2 shared Stephan A. MülleriD· 2 shared Alessio Vittorio ColomboiD· 1 shared Andrew P. LiebermaniD· 1 shared C. P. BlobeliD· 1 shared Christian HaassiD· 1 shared Georg JocheriD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Sabina TahirovićORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The late onset Alzheimer's disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis

Georg Jocher, Stephan A. Müller, Hung‐En Hsia, Miranda Lastra Osua, Gözde Özcelik, Laura I. Hofmann, Marlene Aßfalg, Lina Dinkel, Xiao Ming Feng, Kai Schlepckow, Michael Willem, Christian Haass, Sabina Tahirović, C. P. Blobel, Stefan F. Lichtenthaler

This study identifies iRhom2 as a modifier of ADAM17-mediated TREM2 proteolysis in microglia, linking it to Alzheimer's disease risk.

Life Science Alliance · Mar 13, 2025Peer-reviewedBiochemistry

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Alessio Vittorio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastián Monasor, Martina Schifferer, Ludovico Cantuti‐Castelvetri, Jasmin König, Lea Vidatic, Tatiana Brémovà-Ertl, Andrew P. Lieberman, Silva Katusic Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Leo Strupp, Susanne A. Schneider, Sabina Tahirović

This study shows that loss of NPC1 in microglia increases phagocytic uptake and impairs lipid trafficking, leading to myelin accumulation and potential therapeutic implications.

Nature Communications · Feb 24, 2021Peer-reviewedNeuroscience