Convective forces increase rostral delivery of intrathecal antisense oligonucleotides in the cynomolgus monkey nervous system
Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura L. Horky, Nicolas V. Currier, Bethany Fitzsimmons, Jacob Y. Hesterman, Rachel Pauplis, Scott Haller, Berit E. Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly B. Kordasiewicz, Eric E. Swayze, Ajay Verma
This study shows that increasing convective forces after intrathecal injection improves rostral distribution of therapeutic ASOs in the CNS of cynomolgus monkeys.
Journal of Translational Medicine · Aug 8, 2020Peer-reviewedNeuroscience