Author

Bethany Fitzsimmons

Ionis Pharmaceuticals (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Curt MazuriD· 2 shared Hien Tran ZhaoiD· 2 shared Holly B. KordasiewicziD· 2 shared Ajay VermaiD· 1 shared Arkady KhoutorskyiD· 1 shared Bea DeBrosse-Serra· 1 shared Berit E. PowersiD· 1 shared Briana Noble· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersNeuroscience

Curt MazurORCID

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Author profile →

3 papers

Recent·Most cited

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Kevin C. Lister, Calvin Wong, Sonali Uttam, Marc Parisien, Patricia Stecum, Nicole Brown, Weihua Cai, David Ho-Tieng, Mehdi Hooshmandi, Ning Gu, Mehdi Amiri, Francis Beaudry, Seyed Mehdi Jafarnejad, Diana Tavares‐Ferreira, Nikhil Nageshwar Inturi, , Arkady Khoutorsky

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

eLife · Mar 31, 2026Peer-reviewedNeuroscience

Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide

Kauê Franco Malange, Júlia Borges Paes Lemes, Briana Noble, Yuvicza Anchondo, Carlos Eduardo Morado-Urbina, Saee Jadhav, Sara Anna Dochnal, Chiraag Kambalimath, Pedro Álvarez, Bethany Fitzsimmons, Curt Mazur, Holly B. Kordasiewicz, Kim Doré, Hien Tran Zhao, Tony L. Yaksh

This study evaluates the analgesic effects of intrathecal NaV 1.7 antisense oligonucleotides in rats, showing reduced channel binding and pain behaviors with concentration-dependent knock-down of Scn9a mRNA.

bioRxiv · May 19, 2025 · PreprintNeuroscience

Convective forces increase rostral delivery of intrathecal antisense oligonucleotides in the cynomolgus monkey nervous system

Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura L. Horky, Nicolas V. Currier, Bethany Fitzsimmons, Jacob Y. Hesterman, Rachel Pauplis, Scott Haller, Berit E. Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly B. Kordasiewicz, Eric E. Swayze, Ajay Verma

This study shows that increasing convective forces after intrathecal injection improves rostral distribution of therapeutic ASOs in the CNS of cynomolgus monkeys.

Journal of Translational Medicine · Aug 8, 2020Peer-reviewedNeuroscience