Author

Jacob Y. Hesterman

Invicro (United Kingdom)ORCID 0000-0002-0282-9993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1 Assay:imaging· 1 Organism:non-human primate· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay VermaiD· 1 shared Anant DaduiD· 1 shared Andrew SingletoniD· 1 shared Bea DeBrosse-Serra· 1 shared Berit E. PowersiD· 1 shared Bethany Fitzsimmons· 1 shared Brian AvantsiD· 1 shared Curt MazuriD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Ajay VermaORCID

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Author profile →

2 papers

Recent·Most cited

Application of Aligned-UMAP to longitudinal biomedical studies

Anant Dadu, Vipul K. Satone, Rachneet Kaur, Mathew J. Koretsky, Hirotaka Iwaki, Yue Andy Qi, Daniel M. Ramos, Brian Avants, Jacob Y. Hesterman, Roger N. Gunn, Mark Cookson, Michael Emmerson Ward, Andrew Singleton, Roy H. Campbell, Mike A. Nalls, Faraz Faghri

This paper applies Aligned-UMAP to longitudinal biomedical datasets to reveal time-dependent patterns and provides best practices for its use.

Patterns · Jan 1, 2022Peer-reviewedBioinformatics

Convective forces increase rostral delivery of intrathecal antisense oligonucleotides in the cynomolgus monkey nervous system

Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura L. Horky, Nicolas V. Currier, Bethany Fitzsimmons, Jacob Y. Hesterman, Rachel Pauplis, Scott Haller, Berit E. Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly B. Kordasiewicz, Eric E. Swayze, Ajay Verma

This study shows that increasing convective forces after intrathecal injection improves rostral distribution of therapeutic ASOs in the CNS of cynomolgus monkeys.

Journal of Translational Medicine · Aug 8, 2020Peer-reviewedNeuroscience